Catalog of porcine genes of interest
in endocrinology and reproduction

64 loci


This page was prepared by A. G. Amador & R. King and mirrorred from its original site.

CHROMOSOME #
123456789
12131415161718XY

CHROMOSOME #1: 5 loci.
LocationSymbolName
1p25-p24ESRestrogen receptor
1q15-q16CGApituitary glycoprotein hormone, alpha polypeptide
1q25IFNAinterferon, alpha, leukocyte
1q25-q26IFNB1interferon, beta 1
1q28-q29RLNrelaxin


CHROMOSOME #2: 4 loci.
LocationSymbolName
2p16-p12FSHBfollitropin, beta polypeptide
2q11-q21INSRinsulin receptor
2q12-q13LCIPLeydig cell insulin-like protein
2PDGFRBplatelet-derived growth factor receptor, beta polypeptide

CHROMOSOME #3: 7 loci.
LocationSymbolName
3p13-p11PRM1protamine 1
3p12-p11TNP2transition protein 2
3q11-q13IL1Ainterleukin 1 alpha
3q11-q14IL1Binterleukin 1 beta
3q22-q23FSHRfollitropin receptor
3q22-q23LHCGRlutropin/choriogonadotropin receptor
3PRM2protamine 2

CHROMOSOME #4: 5 loci.
LocationSymbolName
4q15-q24NGFBnerve growth factor, beta polypeptide
4AFDabdominal fat deposition
4HSPheat shock protein
4TGRtotal growth rate (birth to 70 kg)
4TSHBthyrotropin (thyroid stimulating hormone), beta polypeptide

CHROMOSOME #5: 3 loci.
LocationSymbolName
5p15ACRprepro-acrosin
5p12-q11IFNGinterferon, gamma
5q23-q24IGF1insulin-like growth factor 1

CHROMOSOME #6: 7 loci.
LocationSymbolName
6cen-q12LIPElipase, hormone sensitive
6cen-q21TGFB1transforming growth factor, beta 1
6q11-q12CRC (HAL, RYR1)calcium release channel (ryanodine receptor; halothane sensitivity; malignant hyperthermia)
6q21LHBlutropin, beta polypeptide
6q31-q33PRKACBprotein kinase, cAMP-dependent catalytic, beta 1
6BNP1brain natriuretic peptide
6OTF2octamer binding transcription factor 2

CHROMOSOME #7: 5 loci.
LocationSymbolName
7p11HSPA1heatshock protein 70 kDa protein 1
7p11-q11TNFAtumor necrosis factor, alpha
7p11-q11TNFBtumor necrosis factor, beta
7CYP21cytochrome P450, subfamily XXI (steroid 21-hydroxylase)
7PRLprolactin

CHROMOSOME #8: 4 loci.
LocationSymbolName
8cen-q12PDGFRAplatelet-derived growth factor receptor, alpha
8q12 ALBalbumin
8q12-qterIL2interleukin 2
8Idominant white (inhibition of color; patch; roan)

CHROMOSOME #9: 1 locus.
LocationSymbolName
9OTF11octamer binding transcription factor 11

CHROMOSOME #12: 6 loci.
LocationSymbolName
12p14GHsomatotropin
12p14PRKAR1Aprotein kinase, cAMP-dependent regulatory type I alpha
12q12-q14TP53tumour protein p53
12qINHBAinhibin beta A
12 ALOX12arachidonate 12-lipoxygenase
12INHBBinhibin beta

CHROMOSOME #13: 3 loci.
LocationSymbolName
13q31TFtransferrin
13IGRinitial growth rate (birth to 30 kg)
13PIT1pituitary-specific transcription factor (growth hormone factor 1)

CHROMOSOME #14: 3 loci.
LocationSymbolName
14q22-q23RYR2ryanodine receptor, cardiac muscle
14q24-q25HSPA6heatshock protein 70 kDa protein 6
14q24-q26PLAUplasminogen activator, urokinase

CHROMOSOME #15: 2 loci.
LocationSymbolName
15p12-p13LCTlactase
15q24-q25TNP1transition protein 1

CHROMOSOME #16: 2 loci.
LocationSymbolName
16q13-q14FSAfollistatin
16q13-q14GHRsomatotropin receptor

CHROMOSOME #17: 1 locus.
LocationSymbolName
17ENDOdynorphin

CHROMOSOME #18: 3 loci.
LocationSymbolName
18q24IGFBP3insulin-like growth factor binding protein 3
18q24INHBAinhibin beta A
18qCFTRcystic fibrosis transmembrane conductance regulator

CHROMOSOME X: 1 locus.
LocationSymbolName
X ZFXzinc finger protein, X-linked

CHROMOSOME Y: 2 loci.
LocationSymbolName
Yp13-p12SRYsex determining region Y
Y ZFYzinc finger protein, Y-linked

REFERENCES
General

Archibald AL, Haley CS, Brown JF, Couperwhite S, McQueen HA, Nocholson D, Coppieters W, Van de Weghe A, Stratil A, Wintero AK, Fredholm M, Larsen NJ, Nielsen VH, Milan D, Woloszyn N, Robic A, Dalens M, Riquet J, Gellin J, Caritez J-C, Burggaud G, Ollivier L, Bidanel J-P, Vaiman M, Renard C, Geldermann H, Davoli R, Ruyter D, Verstege EJM, Groenen MAM, Davies W, Hoyheim B, Keiserud A, Andersson L, Ellegren H, Johansson M, Marklund L, Miller JR, Dear DVA, Signer E, Jeffreys AJ, Moran C, Le Tissier P, Muladno, Rothschild MF, Tuggle CK, Vaske D, Helm J, Liu H-C, Rahman A, Yu T-P, Larson RG, Schmitz CB. The PigMap consortium linkage map of the pig (Sus scrofa). Mammal Genome 1995;6:157-75.

Andersson L, Archibald AL, Gellin, Schook LB. 1st pig gene mapping workshop (PGM1), 7 august 1992, Interlaken, Switzerland. Anim Genet 1993;24:205-16.

Echard G, Milan D, Yerle, Lahbib-Mansais Y, Gellin J. The gene map of the pig (Sus scrofa domestica L.): a review. Cytogenet Cell Genet 1992;61:146-51.

Ellegren H, Chowdhary BP, Johansson M, Fredholm M, Gustavsson, Andersson L. A primary linkage map of the porcine genome reveals a low rate of genetic recombination. Genetics 1994;137:1089-100.

Johansson M, Ellegren H, Andersson L. Comparative mapping reveals extensive linkage conservation-but with gene order rearrangements-between the pig and the human genomes. Genomics 1995;25:682-90.

Yerle M, Lahbib-Mansais Y, Mellink C, Goureau A, Pinton P, Echard G, Gellin J, Zijlstra C, De Haan N, Bosma AA, Chowdhary B, Gu F, Gustavsson I, Thomsen PD, Christensen K, Rettenberger G, Hameister H, Schmitz A, Chaput B, Frelat G. Mammal Genome 1995;6:176-86.


Chromosome #1

Ellegren H. Abundant (A)n-(T)n mononucleotide repeats in the pig genome: linkage mapping of the porcine APOB, FSA, ALOX12, PEPN and RLN loci. Anim Genet 1993;24:367-72.

Ellegren H, Chowdhary BP, Fredholm M, Hoyheim B, Johansson M, Braeuner Nielsen P, Thomsen PD, Andersson L. Aphysically anchored linkage map of pig chromosome 1 uncovers sex- and position-specific recombination rates. Genomics 1994;24:342-50.

Sarmiento UM, Sarmiento JI, Lunney JK, Rishi SS, Mapping of the porcine alpha interferon (IFNA) gene to chromosome #1 by fluoresecence in situ hybridization. Mammal Genome 1993;4:62-3.

Troyer DL, Xie H, Goad DW, Skinner DZ. Use of a new technique to map the porcine alpha interferon gene to chromosome 1. Mammal Genome 1994;5:112-4.

Yerle M, Gellin J, Echard G, Lefevre F, Gillois M. Chromosomal localization of leukocyte interferon gene in the pig (Sus scrofa domestica) by in situ hybridization. Cytogenet Cell Genet 1986;42:129-32.


Chromosome #2

Gu F, Harbitz I, Chowdhary BP, Bosnes M, Gustavsson I. Chromosomal localization of the hormone sensitive lipase (LIPE) and insulin receptor (INSR) genes in pigs. Hereditas 1992;117:231-6.

Rettenberger G, Burkhardt E, Adham IM, Engel W, Fries R, Klett C, Hameister H. Assignment of the Leidig insulin-like hormone to porcine chromosome 2q12-q13 by somatic cell hybrid analysis and fluorescence in situ hybridization. Mammal Genome 1994;5:307-9.

Rohre GA, Alexander LJ, Beattie CW. Mapping the beta subunit of follicle stimulating hormone (FSHB) in the porcine genome. Mammal Genome 1994;5:315-7.


Chromosome #3

Gu F, Chowdhary BP, Johansson M, Andersson L, Gustavsson I. Localization of the IGHG, PRKACB, and TNP2 genes in pigs by in situ hybridization. Mammal Genome 1994;5:195-8.

Johansson M, Ellegren H, Marklund L, Coppieters W, Andersson L. Linkage maps of porcine chromosomes 3, 6, and 9 based on 31 polymorphic markers. Mammal Genome 1994;5:785-90.

Mellink C, Lahbib-Mansais Y, Yerle M, Gellin J. Mapping of the regulatory type I alpha and catalytic beta subunits of cAMP-dependent protein kinase and interleukin 1 alpha and 1 beta in the pig. Mammal Genome 1994;5:298-302.

Rettenberger G, Fries, R. Engel, Scheit KH, Dolf G, Hameister H. Establishement of a partially informative porcine somatic cell hybrid panel and assignment of the loci for transition protein 2 (TNP2) and protamine 1 (PRM1) to chromosome 3 and polyubiquitin (UBC) to chromosome 14. Genomics 1994;21:558-66.


Chromosome #4

Andersson L, Haley CS, Ellegren H, Knott SA, Johansson M, Andersson K, Andersson-Eklund L, Edfors-Lija I, Fredholm M, Hansson I, Haekansson J, Lundstroem K. Genetic mapping of quantitative loci for growth and fatness in pigs. Science 1994;263:1771-4.


Chromosome #5

Rettenberger G, Adham IM, Engel W, Klett C, Hameister H. Assignment of the porcine acrosin gene, ACR, to chromosome 5p15 by fluorescence in situ hybridization (FISH). Mammal Genome 1995;6:60-1.

Winteroe AK, Fredholm M, Andersson L. Assignment of the gene for porcine insulin-like growth factor 1 (IGF1) to chromosome 5 by linkage mapping. Anim Genet 1994;25:37-9.


Chromosome #6

Gu F, Chowdhary BP, Johansson M, Andersson L, Gustavsson I. Localization o fthe IGHG, PRKACB, and TNP2 genes in pigs by in situ hybridization. Mammal Genome 1994;5:195-8.

Johansson M, Ellegren H, Marklund L, Coppieters W, Andersson L. Linkage maps of porcine chromosomes 3, 6, and 9 based on 31 polymorphic markers. Mammal Genome 1994;5:785-90.

Mellink C, Lahbib-Mansais Y, Yerle M, Gellin J. Mapping of the regulatory type I alpha and catalytic beta subunits of cAMP-dependent protein kinase and interleukin 1 alpha and 1 beta in the pig. Mammal Genome 1994;5:298-302.


Chromosome #7

Solinas S, Pauli U, Kuhnert P, Peterhans E, Fries R. Assignment of the porcine tumour necrosis factor alpha and beta genes to the chromosome region 7p11-q11 by in situ hybridization. Anim Genet 1992;23:267-71.


Chromosome #8

Johansson M, Ellegren H, Marklund L, Gustavsson U, Ringmar-Cederberg E, Andersson K, Edfors-Lilja I, Andersson L. The gene for Dominant White color in the pig is closely linked to ALB and PDGFRA on chromosome 8. Genomics 1992;14: 965-969.


Chromosome #12

Ellegren H. Abundant (A)n-(T)n mononucleotide repeats in the pig genome: linkage mapping of the porcine APOB, FSA, ALOX12, PEPN and RLN loci. Anim Genet 1993;24:367-72.

Mellink C, Lahbib-Mansais Y, Yerle M, Gellin J. Mapping of the regulatory type I alpha and catalytic beta subunits of cAMP-dependent protein kinase and interleukin 1 alpha and 1 beta in the pig. Mammal Genome 1994;5:298-302.

Rettenberger G, Klett C, Hameister H. Localization of tumor protein, TP53, on porcine chromosome 12q12-q14. Anim Genet 1993;24:307-9.

Thomsen PD, Fredholm M, Christensen K, Schwerin M. Assignment of the porcine growth hormone gene to chromosome 12. Cytogenet Cell Genet 1990;54:92-4.

Yerle M, Lahbib-Mansais Y, Thomsen PD, Gellin J. Localization of the porcine growth hormone gene to chromosome 12p12-p15. Anim Genet 1993;24:129-31.


Chromosome #13

Andersson L, Haley CS, Ellegren H, Knott SA, Johansson M, Andersson K, Andersson-Eklund L, Edfors-Lija I, Fredholm M, Hansson I, Haekansson J, Lundstroem K. Genetic mapping of quantitative loci for growth and fatness in pigs. Science 1994;263:1771-4.


Chromosome #14

Leeb T, Rettenberger G, Hameister H, Brem G, Brenig B. Construction of a porcine YAC library and mapping of the cardiac muscle ryanodine receptor gene to chromosome 14q22-q23. Mammal Genome 1995;6:37-41.


Chromosome #15

Rettenberger G, Adham IM, Engel W, Klett C, Hameister H. Assignment of the porcine transition protein TNP1 to chromosome 15q24-q25 by fluorescence in situ hybridization (FISH). Mammal Genome 1994;5:249-50.


Chromosome #16

Chowdhary BP, Ellegren H, Johansson M, Andersson L, Gustavsson I. In situ hybridization mapping of the growth hormone receptor (GHR) gene assigns a linkage group (C9, FSA, GHR, and S0105) to chromosome 16 in pigs. Mammal Genome 1994;5:160-2.

Ellegren H. Abundant (A)n-(T)n mononucleotide repeats in the pig genome: linkage mapping of the porcine APOB, FSA, ALOX12, PEPN and RLN loci. Anim Genet 1993;24:367-72.


Chromosome #18

Lahbib-Mansais Y, Yerle M, Pinton P, Gellin J. Chromosomal localization of homeobox genes and associated markers on porcine chromosomes 3, 5, 12, 15, 16 and 18: comparative mapping study with human and mouse. Mammal Genome 1996;7:174-9.


Chromosome Y

Yang H, Fries R, Strnazinger G. The sex-determining region Y (SRY) gene is mapped to p12-p13 of the Y chromosome in pig (Sus scrofa domestica) by in situ hybridization. Anim Genet 1993;24:297-300.


Armando G. Amador
© A. G. Amador & R. King
Last update: Saturday, 27 December, 1997 20:30:03


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